Freeze-Dried Matrices for Buccal Administration of Propranolol in Children: Physico-Chemical and Functional Characterization

Buccal matrices represent a widely accepted dosage form permitting convenient, easy, reliable drug administration and reducing errors. The aim of this study was the development mucoadhesive buccal for propranolol in children. Matrices were obtained by freeze-drying loaded polymeric solutions based on gum tragacanth (GT), pectin (PEC), hydroxypropylmethylcellulose (HPMC), sodium hyaluronate (HA), gelatin (GEL), chitosan (CH) or mixture CH HPMC (CH/HPMC). characterized solid state, morphology, water-uptake, mucoadhesion ability, vitro release permeation through porcine epithelium. most promising formulations tested biocompatibility human dental pulp fibroblasts. preparative method composition influenced as complete amorphization well different polymorphic forms observed. GEL PEC guaranteed fast due to their rapid dissolution, while other diffusion viscous gelled matrix. Moreover, CH/HPMC showed best properties, favoured permeation, virtue ability interfere with lipid organization biological membrane, good profile.